Which group is most at risk for developing symptoms of C-Diff?

The group most at risk for developing symptoms of Clostridium difficile (C-Diff) infection is residents with low resistance. Individuals with low resistance typically have compromised immune systems due to factors such as advanced age, chronic illnesses, recent antibiotic use, or prolonged hospitalization. A weakened immune system makes it harder for the body to fight off infections like C-Diff.

When the normal gut flora is disrupted—often following antibiotic treatment—C-Diff can proliferate, leading to symptoms such as diarrhea, abdominal pain, and in severe cases, colitis. Therefore, those with low resistance are particularly susceptible to developing serious symptoms after infection.

In contrast, other groups such as young, healthy individuals or those with high resistance are generally less susceptible to developing significant symptoms from C-Diff, as they have a more robust immune response and a healthy gut microbiome that can help prevent the overgrowth of harmful bacteria.